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Massive blood transfusion Massive blood transfusion may be defined as the replacement of one blood volume (equivalent to 10 units of blood) in any 24 hour period or half of the volume ( 5 units of blood) in any four hour period in an adult. Replacemnt of a blood volume equivalent within 24 hours. 10 units within 24 hours Transfusion 4 units in 1 hour Replacemnt of 50% of blood volume in 3-4 hours A rate of loss 150ml/hour Example: Masive blood transfusion occurs in settings such as trauma, ruptred aortic